Background:
Because antibodies cannot enter cells, past experiments using antibodies focused primarily on extracellular molecules.If target molecules in living cells can be exposed to antibodies, it will be possible to pursue new dimensions of research related to cell function analysis, exploration of target molecules for disease diagnosis and treatment, and so on. GenomONE-CAb Antibody Delivery Reagent is a next-generation tool for antibody introduction into cells which can meet such needs.With this kit, antibody can be incorporated into the HVJ Envelope (HVJ-E), a transfection tool making use of the membrane fusing ability of inactivated Sendai virus (HVJ: Hemagglutinating Virus of Japan). If cells are treated with HVJ-E including antibody, it will be possible to achieve efficient introduction of IgG antibodies into the cytoplasm. This kit provides a totally new methodology for experiments, overcoming the difficulties involved in experiments using conventional lipid-based reagents by which antibodies are introduced into cells by means of endocytosis.