TRANSIL� Brain
Absorption Kit
A ready-to-use kit for rapid
assessment of drugs' ability to cross the blood brain
barrier
A novel ready-to-use kit designed for rapid assessment of
drug candidates' ability to cross the blood brain barrier.
The kit only requires the addition of drug candidates to the
microtiter wells followed by a 2-minute incubation. The kit
assesses the affinity of the drug candidates to brain
membrane. Membrane affinity is directly related to
permeation and blood-to-brain absorption of a drug.
Benefits
- Fast, requiring only 2 minutes for
incubation.
- Accurate. Measures the affinity of
the drug candidate to the brain membrane. More
accurate classification of CNS compounds
measured by brain availability and brain
membrane affinity, compared to PAMPA BBB
(Parallel Artificial Membrane Permeability Assay
Blood Brain Barrier) (86% vs. 62%,
respectively).
- Reliable with highly reproducible
results, and robust correlation to dialysis.
- Relevant. Used in combination with
plasma binding protein data, determine the free
fraction in brain and the equilibrium
distribution of drug compounds between blood and
brain tissue.
- Ready-to-use format plated in 96-well
or ready-to-use tubes in strips of 8. Kit
requires only addition of test material,
2-minute incubation, and quantification.
- Flexible. Adaptable to automation.
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Product Information
Product Number |
Product Name |
Format |
TMP-0110-0096 |
Transil�
Brain Absorption Kit |
96-well
plate |
TMP-0110-1196 |
Transil�
Brain Absorption Kit |
96-well
(strips) |
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