LINEAR NF-κB Decoy Oligonucleotides Kits and RIBBON NF-κB Decoy Oligonucleotides Kits

Background:

Painful inflammatory diseases such as rheumatoid arthritis and atopic dermatitis are currently treated primarily symptomatically, through the use of analgesics. Thus, there is a great need for novel therapeutics targeting the underlying inflammatory mechanisms. NF-κB is an intensively studied transcription factor well known for its role in stimulating the production of inflammatory cytokines. Recently, NF-κB decoy nucleic acids have gained considerable attention as potential therapeutics for inflammatory disease due to their ability to inhibit NFκB-mediated production of inflammatory cytokines, by preventing NF-κB from binding to its native DNA binding sites. Preliminary studies with NF-κB decoys indicate efficacy in reducing both pain and itch.

First generation NF-κB decoy nucleic acid drugs were linear DNA duplexes. Such drugs suffered not only from poor cellular uptake, but also from serum half-life due to poor resistance to nucleases. Subsequently, a circular (ribbon) form of NF-κB decoy was developed with improved nuclease resistance and significantly longer half-life.

Kit component:

Offered here are NF-κB decoy oligodeoxynucleotides kits for our own research. Each kit contains the specified oligo and a control oligo with an identical base composition but different sequence that does not bind NF-κB. Phosphorotioate-modified kits are also offered. Please see the individual product datasheets for exact specifications. All oligos are purified by HPLC

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RIBBON NFκB Decoy Oligonucleotides Kit	GDS-DN-25101	2*0.5 MG	�600
RIBBON NFκB Decoy Oligonucleotides Kit	GDS-DN-25102	2*0.5 MG	�677
NFκB decoy Oligonucleotides Kit	GDS-DN-15101	2*1 MG	�447
NFκB decoy Oligonucleotides Kit	GDS-DN-15102	2*1 MG	�524
NFκB decoy Oligonucleotides Kit	GDS-DN-15103	2*1 MG	�485